Pim3 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comPim3 Polyclonal Antibody for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Pim3(Gene name) > Mouse

Pim3 (Gene name),

Serine/threonine-protein kinase pim-3 (Protein name ), PIM3_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Pim3;

Protein name:

Serine/threonine-protein kinase pim-3;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with BAD (By similarity). Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM3, ubiquitination and proteasomal degradation (By similarity). Interacts with SOCS6.

Function:

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

326

Sequence:

50:

100:

150:

200:

250:

300:

326:

PENCDLRLCA | LDTDDGASTT | SSSESL

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

KEGG:

mmu:223775

String:

P58750

UniGene:

Mm.400129

SMR:

P58750

Pfam:

PF00069

Uniprot:

P58750

FOR

ELISA Kit for Mouse Serine/threonine-protein kinase pim-3

Cat.:

E4599m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Mouse Serine/threonine-protein kinase pim-3

Cat.:

E4599r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Mouse Serine/threonine-protein kinase pim-3

Cat.:

E4599h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Mouse Serine/threonine-protein kinase pim-3

Cat.:

U4599h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Mouse Serine/threonine-protein kinase pim-3

Cat.:

U4599r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Serine/threonine-protein kinase pim-3

Cat.:

U4599m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse Serine/threonine-protein kinase pim-3

Cat.:

P4599Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Serine/threonine-protein kinase pim-3

Cat.:

P4599Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Serine/threonine-protein kinase pim-3

Monoclonal Antibody for Mouse Serine/threonine-protein kinase pim-3

Protein for Mouse Serine/threonine-protein kinase pim-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Colon.
tissue: Salivary gland.
2.

"Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors."
Mikkers H. , Nawijn M. , Allen J. , Brouwers C. , Verhoeven E. , Jonkers J. , Berns A.
Mol. Cell. Biol.24:6104-6115(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
3.

"Pim3 negatively regulates glucose-stimulated insulin secretion."
Vlacich G. , Nawijn M.C. , Webb G.C. , Steiner D.F.
Islets2:308-317(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DISRUPTION PHENOTYPE;INTERACTION WITH SOCS6;INDUCTION;MUTAGENESIS OF LYS-38;FUNCTION
4.

"The Pim protein kinases regulate energy metabolism and cell growth."
Beharry Z. , Mahajan S. , Zemskova M. , Lin Y.W. , Tholanikunnel B.G. , Xia Z. , Smith C.D. , Kraft A.S.
Proc. Natl. Acad. Sci. U.S.A.108:528-533(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

Product Feedback Wall

* Email:
*Comments: